Aorta + endovascular stent graft + huge market

Endospan’s NEXUS aortic arch stent system is a modular branched stent designed specifically for total endovascular aortic arch repair. Its core innovation lies in its dual-module “Dock and Lock” architecture.

The NEXUS dual-module design features a unique dual-module structure. The main module covers the aortic arch and descending aorta, integrating a collateral branch for brachiocephalic trunk revascularization. The ascending aortic module is placed within the ascending aorta, and the two are securely connected via a mechanical locking system. The system offers single-branch, dual-branch, and triple-branch configurations to meet different supra-aortic vessel reconstruction needs.

The core technology of the Dock and Lock mechanism lies in the active locking system between the modules. The distal end of the ascending aortic module features an exposed metal stent structure that mechanically interlocks with the proximal annular structure and lateral self-expanding sleeve of the main module. Once locked, the stent engagement device is anchored within the docking sleeve, providing strong dissociation resistance and effectively preventing module displacement, dissociation, and type III endoleak.

The pre-bent delivery system, with both modules pre-shaped to the natural curvature of the aortic arch, significantly reduces instrument manipulation and friction, lowering the risk of intraoperative embolism. The directional ascending aortic component features a directional bending design that precisely conforms to the anatomy of the ascending aorta, avoiding the “bird’s beak” effect and optimizing sealing performance. Low-profile delivery allows for endovascular procedures via a 20F sheath through the femoral artery, eliminating the need for a neck incision. Hemodynamic optimization ensures continuous intraoperative perfusion of the brain and descending aorta after implantation of the main module. Preoperative debranching of the supra-aortic vessels is required to divert blood flow from the brachiocephalic trunk to the left common carotid artery and left subclavian artery, thereby reducing the risk of intraoperative cerebral embolism related to aortic arch manipulation.